Welcome to the Yadav Lab

We investigate how dynamic, tissue-specific redox stress—particularly hydrogen peroxide (H₂O₂) signaling—regulates neuro-metabolic communication across brain-body axes, including the brain-pancreas, brain-heart, and brain-gut systems, and how its dysregulation drives disease.

Our work focuses on how neuronal oxidative stress perturbs vagal sensory circuits. This disrupts coordination between organs and leads to systemic metabolic and physiological dysfunction. To dissect these processes, we use chemogenetic control of H₂O₂ signaling (the HyPer–DAAO system) alongside in vitro, ex vivo, and in vivo models, allowing us to precisely reshape redox states and observe their effects on organ-specific signaling and cellular function.

We integrate multi-omics data with deep learning and graph neural networks to model signaling networks and predict how circuits respond to redox perturbation—helping us define the fundamental principles of redox-mediated brain-body communication and identify strategies to restore healthy physiological coordination.

Our Mission Statement

We believe that strong science is built through mentorship, intellectual honesty, and fearless questioning. Our training environment is designed to cultivate independent scientists who can move fluidly between molecular mechanisms and systems-level understanding.

By following these guiding principles, we provide a fertile ground for training the next generation of scientists, educators, innovators, entrepreneurs, and leaders.